不同化疗方案治疗恶性滋养细胞肿瘤的效果比较

Comparison of the efficacy of two kinds of chemotherapy schemes for treatment of gestational trophoblastic tumor

目的比较不同化疗方案治疗恶性滋养细胞肿瘤的临床效果。方法选取2010—2015年在河南省肿瘤医院治疗的恶性滋养细胞肿瘤患者137例,分为A组和B组,其中A组73例,B组64例。A组采用EMA/CO化疗方案,B组采用5-氟尿嘧啶单药化疗,对两组治疗效果及毒性反应进行比较。结果 A组治疗有效率为91.8%,B组治疗有效率为75.0%,两组有效率比较,差异有统计学意义(P<0.05)。两组骨髓抑制发生率比较,差异无统计学意义(P>0.05);两组口腔黏膜损伤及胃肠道反应(恶心呕吐、腹泻)发生率比较,差异有统计学意义(P<0.05)。结论 EMA/CO化疗方案可以有效治疗恶性滋养细胞肿瘤,且毒副作用轻,患者易于接受,适合在临床中推广应用。

Objective To compare the different efficacy of two kinds of chemotherapy schemes for treatment of gestational tro- phoblasite tumor （GTr）. Methods 137 patients with GTT admitted to henan provincial cancer hospital from 2010 to 2015 were divided into EMA/CO chemotherapy group A （ n = 73） and 5 - Fu chemotherapy group B （ n = 64）. The effective rate and ad- verse reaction were analyzed and compared between the two groups. Results The effective rate of the group A was 91.8%, the effective rate of the group B was 75.0% , the difference between the two group was signifieant（P 〈0. 05）. There was no signifi- cant difference in bone marrow depression between the two groups, hut there were significant differences in nausea and vomiting, diarrhea, and oral ulcer between the two groups. Conclusion EMO/CO chemotherapy scheme can effectively treat the GTr pa- tients, and it is suitable for clinical application.