玻璃酸钠治疗中度膝关节骨性关节炎的远期效果观察

Long-term effects of sodium hyaluronate in the treatment of mid-knee octeoarthritis

目的研究分析玻璃酸钠治疗中度膝关节骨性关节炎的远期效果。方法将68例中度膝关节骨性关节炎患者随机分为观察组(玻璃酸钠膝关节腔内注射治疗,34例)和对照组(口服药物治疗,34例),对比两组患者临床治疗总有效率,治疗前后SDS评分、SAS评分、VAS评分变化状况及治疗后患者生活质量改变状况。结果观察组患者治疗总有效率为97.1%,同对照组患者的70.6%相比差异具有显著性(P<0.05);治疗前,两组患者SDS评分、SAS评分、VAS评分相比差异无显著性(P>0.05);治疗后,观察组患者SDS评分、SAS评分、VAS评分均低于对照组患者(P<0.05);且观察组患者治疗后躯体功能评分、社会功能评分、心理功能评分和物质生活评分均显著高于对照组患者(P<0.05)。结论在治疗中度膝关节骨性关节炎中玻璃酸钠膝关节腔内注射措施能有效提高患者临床治疗总有效率、改善患者治疗后SDS评分、SAS评分、VAS评分和生活质量状况。

Objective To study the long-term effect of sodium hyaluronate in treating knee osteoarthritis. Methods 68 moderate knee osteoarthritis patients were randomly divided into the observation group （34 cases of intra-articular injection of sodium hyaluronate treatment） and control group （oral drug therapy,34 cases）. Clinical comparison of two group＇s patients was taken in total efficiency,SDS score,SAS score before and after treatment, VAS score changes after treatment and quality of life in patients. Results Total efficiency of the observation group was 97.1%,compared with the control group （70.6%） with significant difference （P〈0.05）;before treatment between two groups patient＇s,SDS score,SAS score,VAS score,had no significant difference （P〉0.05）;after treatment,the observation group patients SDS score,SAS score,VAS score were lower than those in control group （P〈0.05） ;scores of physical function in the observation group after treatment,and the score of social function, psychological function and score material life scores were significantly higher than that in control group （P〈0.05）. Conclusion In the treatment of moderate knee osteoarthritis clinical intra-articular injection of sodium hyaluronate measures can effectively improve the clinical treatment of patients with total effficiency,improve the treatment of patients with SDS score,SAS score,VAS score and quality of life.