华东地区自然人群血清维生素D水平调查

Serum vitamin D levels of the natural population in eastern China

目的 了解中国华东地区自然人群的维生素D水平，为该地区人群预防维生素D缺乏及其相关疾病提供依据。方法 数据来源于2014年中国华东地区代谢性疾病的患病率及危险因素的横断面研究数据库，年龄≥18岁目前居住于此区域或居住时间≥6个月的成年人12 662名纳入此项研究。以血清25-羟维生素D（25-OHD）〈50 nmol/L定义为维生素D缺乏，评估中国华东地区自然人群的血清维生素D水平。偏态分布资料用中位数（四分位间距）表示。结果 中国华东地区自然人群的血清25-OHD水平为（40.5±12.5）nmol/L，维生素D缺乏率为80.3%；女性血清25-OHD水平明显低于男性，差异有统计学意义（P〈0.05）；男性各年龄段血清25-OHD水平分别为：〈30岁组37.81（31.98-43.52）nmol/L、30-39岁组39.46（33.87-45.72）nmol/L、40-49岁组41.17（34.10-48.65）nmol/L、50-59岁组40.67（34.20-49.02）nmol/L、60-69岁组44.00（35.67-53.93）nmol/L、≥70岁组44.14（34.61-55.85）nmol/L，女性各年龄段血清25-OHD水平分别为：〈30岁组36.86（30.52-43.75）nmol/L、30-39岁组37.11（31.68-43.23）nmol/L、40-49岁组36.94（30.72-43.71）nmol/L、50-59岁组38.42（32.08-46.41）nmol/L、60-69岁组38.58（31.04-46.21）nmol/L、≥70岁组37.31（29.34-47.17）nmol/L。结论 中国华东地区自然人群的维生素D水平普遍偏低，女性维生素D水平低于男性，然而维生素D的水平随着年龄的增长呈上升趋势。

Objective To assess vitamin D levels in eastern China by a standard measurement. Methods The data were from a 2014 Survey on the Prevalence in East China for Metabolic Diseases and Risk Factors-China data base. There were 12 662 subjects included in this cross-sectional study from February 2014 to June 2016. We assessed the vitamin D levels of natural population by a standard classification in which serum 25-hydroxy vitamin D （25-OHD） 〈50 nmol/L was defined as vitamin D deficiency. Results The average serum 25-OHD level was （40.5 ± 12.5 ） nmol/L, and there were 80.3% subjects who would be classified as vitamin D deficiency ; The average serum 25-OHD level of women was significantly lower than that of men （ P〈 0.05 ） ; The serum 25-OHD concentrations of the 〈30, 30-39,40-49,50-59,60-69, 〉I 70 age groups were 37.81 （ 31.98-43.52 ） nmol/L, 39.46 （ 33.87-45.72 ） nmol/L, 41.17 （34. 10-48.65 ） nmol/L, 40.67 （ 34.20-49.02 ） nmolfL, 44.00 （ 35.67-53.93 ） nmol/L, 44. 14 （34.61-55.85） nmol/L for males, and 36.86 （30.52-43.75） nmol/L, 37. 11 （31.68-43.23） nmol/L, 36.94 （30.72-43.71） nmol/L, 38.42 （32.08-46.41） nmol/L, 38.58 （31.04-46.21） nmol/L, 37.31 （29.34-47. 17 ） nmol/L for females in corresponding subgroups. Conclusion The prevalence of vitamin D deficiency of natural population in eastern China was common, the levels of vitamin D in women were lower than those of men. However, the vitamin D levels were tended to be increasing with the advance of age.