硫酸特布他林雾化吸入治疗新生儿暂时性呼吸困难的临床价值

Clinical Value of Terbutaline Sulphate Atomization Inhalation in the Treatment of Neonates with Transient Dyspnea

目的:研究吸入硫酸特布他林雾化液治疗新生儿暂时性呼吸困难(TTN)的作用,并了解其不良反应。方法:2015年5月至2016年4月在永康市第一人民医院诊断为TTN的89例新生儿,根据住院号的单双号分为对照组41例及观察组48例。对照组予常规治疗及雾化吸入生理盐水处理,观察组在常规治疗的基础上予硫酸特布他林雾化液雾化吸入处理,分别记录用药前及应用药物后6 h TTN临床评分、呼吸频率及血气分析变化,同时比较两组的住院时间及用氧时间差异,并观察心率、24 h尿量、血糖、血钾等变化,了解硫酸特布他林雾化液治疗的不良反应。结果:两组治疗后临床疗效、TTN临床评分、氧合指数、呼吸频率比较差异有统计学意义(P<0.05)。两组住院时间、总用氧时间比较差异有统计学意义(P<0.05)。两组治疗前后组内组间心率、24 h尿量、血糖、血钾比较差异无统计学意义(P>0.05)。结论:硫酸特布他林雾化液吸入治疗能明显改善TTN患儿呼吸困难症状,缩短住院时间及用氧时间,且无明显不良反应。

Objective： To evaluate the effect of terbutaline sulphate atomization inhalation in the treatment of transient dyspnea （TTN） in neonates and to research its adverse effects.Methods： From May 2015 to April 2016 in the First People＇s Hospital of Yongkang City,89 cases were diagnosed as neonatal TTN,according to the number of hospitalization were divided into control group 41 cases and observation group 48 cases.The control group was treated with conventional therapy and saline aerosol inhalation,the observation group was treated with terbutaline sulphate atomization inhalation on the basis of conventional treatment.The clinical score,respiratory rate and blood gas analysis were recorded before and after treatment in 6 hours.At the same time,the two groups of hospitalization time and time of oxygen use were compared,the heart rate,24 hour urine volume,blood glucose,blood potassium were observed,the adverse reactions of terbutaline sulphate solution atomization inhalation were understood.Results： After treatment,there were statistically significant differences in the clinical efficacy,TTN clinical score,oxygenation index,respiratory frequency between two groups （P〉0.05）.Two groups of hospitalization time and time of oxygen use were compared,the differences were statistical significance （P〈0.05）.The heart rate,24 hour urine volume,blood glucose,blood potassium in two groups were compared before and after treatment,the differences were not statistical significance （P〉0.05）.Conclusion： Terbutaline sulphate solution atomization inhalation can significantly improve the symptoms of dyspnea in neonates with TTN,shorten the length of stay and oxygen time,and with no significant adverse reaction.