前S1抗原在乙型肝炎病毒诊断和治疗中的研究进展

The advance of the use of Pre-S1 antigen in the diagnosis and therapy of hepatitis B virus infection

前S1抗原是位于乙型肝炎病毒(HBV)颗粒表面的一种膜蛋白。近些年有临床研究显示,前S1抗原在乙肝感染的早期就能出现在血清中,可用于乙肝病毒感染的早期诊断。前S1抗原与HBV-DNA、HBe Ag检测高度符合,是HBV-DNA、HBe Ag检测指标的补充和对照;前S1抗原的转阴时间及持续阳性提示了乙肝病毒感染后的疾病转归。因此,前S1抗原可作为HBV诊断和治疗的重要依据。本文就前S1抗原的结构和功能,其在HBV感染有关的肝脏疾病中的临床应用进行综述。

Pre-S1 antigen is a memhrane protein which is located at the surface of hepatitis B virus （HBV） particle. Recently,a lot of studies suggested Pre-S1 antigen could be detected in blood and used as a marker of the early infection of HBV. The detection of Pre-S1 antigen is highly consistent with the detection of HBV-DNA and HBeAg to be the supplement and reference. The clearance time and continuing positive of Pre-S1 antigen could respectively indicate the prognosis of the infection of HBV. Therefore, Pre-S1 antigen could be used as an important tool for the diagnosis and therapy of hepatitis B virus infection. In this study, we will summarize the structure and function of Pre-S1 antigen and it clinical use in liver diseases associated with hepatitis B virus infection.