新型丝氨酸蛋白酶Corin在心血管病中的研究进展

Research progress of novel serine protease Corin in cardiovascular disease

Corin是一种新近发现的产生于心肌细胞并使心血管活性肽前体酶原向活性肽转化的Ⅱ型跨膜丝氨酸蛋白酶。Corin在降低血容量、调节体液平衡、降血压以及改善心功能方面扮演重要角色,是心力衰竭的一种新的生物标志物。越来越多的研究发现,Corin不仅与心力衰竭有关,而且与高血压、冠心病等心血管疾病的发生发展相关。

Corin is a recently discovered II type transmembrane serine protease, which is produced in cardiomyocytes, and let cardioascular active peptide precursor enzyme converte to bioactive peptide. Corin plays an important role in reducing blood volume, regulating fluid balance, controlling blood pressure and improving heart function, which is a kind of new biomarkers of heart failure. More and more studies have found that Corin is not only related to heart failure, but also related to the development of hypertension, coronary heart disease and other cardiovascular diseases.