基质金属蛋白酶及其组织抑制物在糖尿病足创面愈合中作用的研究概况

Research progress of matrix metalloproteinases and tissue inhibitors of MMPs in diabetic foot ulcer

糖尿病足(diabetic foot,DF)是糖尿病最严重的并发症之一,属难治性创面。基质金属蛋白酶(matrix metalloproteinases,MMPs)具有促进细胞迁移、降解细胞外基质(extracellular matrix,ECM)等作用,参与创面愈合的每个过程。基质金属蛋白酶组织抑制剂(the tissue inhibitors of MMPs,TIMPs)是MMPs的特异性抑制剂,抑制MMPs过度表达。二者协同,在创面愈合中发挥重要作用。该文就MMPs和TIMPs在DF溃疡创面愈合中作用的研究概况进行综述。

Diabetic foot（DF） ulcer is one of the most severe complications, belonging to refractory wound. Matrix metalloproteinases（MMPs） have the effect of degrading extracellular matrix（ECM） and promoting cell migration and involve in all the process of wound healing. Tissue inhibitor of metalloproteinases（TIMPs） which inhibit MMPs overexpression is a specific inhibitor of MMPs. They play an important role in wound healing together. In this paper, the role of MMPs and TIMPs in diabetic foot ulcer wound healing is reviewed.