膀胱肿瘤电切术后动脉化疗治疗浸润性癌的效果

Effect of arterial chemotherapy in the treatment of invasive carcinoma after trans-urethral resection of bladder tumor

目的探讨动脉化疗在膀胱肿瘤电切术后诊断浸润性膀胱癌患者补救治疗的效果和安全性。方法随访2011年1月~2016年5月我院收治的9例膀胱肿瘤电切术后诊断浸润性膀胱癌的患者1~5年,观察其膀胱肿瘤电切术后动脉化疗的效果,分别于术后不同时间返院行B超、尿细胞学、膀胱镜或CT/MRI及胸片等检查,了解患者的存活时间、副作用及肿瘤是否复发和转移。结果 9例患者均完成动脉化疗,过程顺利,无明显不良反应。中位随访时间为34.5个月(14~63个月),2/3的患者(69.6%)显示完全缓解。3年和5年总生存期分别为70.65%、61.23%。在整个随访期间,88.9%患者保留了膀胱。结论动脉化疗可以作为浸润性膀胱癌患者电切术后的补救治疗,膀胱肿瘤电切术后联合动脉化疗可以作为拒绝膀胱癌根治术而要求膀胱保留治疗患者的一个选择。

Objective To investigate the effect and safety of arterial chemotherapy as a remedy on treating patients diagnosed as invasive bladder cancer after trans-urethral resection of bladder tumor（TURBT）.Methods From January2011 to May 2016,9 patients diagnosed as invasive bladder cancer after TURBT were continued for follow-up visits for1-5 years in order to observe the effect of arterial chemotherapy after TURBT.Examinations including B ultrasound,urinary cytology,cystoscope or CT/MRI,and chest X-ray at different times after operation were performed aiming at getting known the survival period,side effects,and recurrence and metastasis or not in these participants.Results All patients were successfully performed with arterial chemotherapy without obvious adverse reactions.The median follow-up visit was 34.5 months（14-63 months）,and two-thirds of the patients were displayed complete remission.The total survival rates for three and five years were 70.65% and 61.23%,respectively.During the entire follow-up period,88.9% of patients retained the bladder.Conclusion Arterial chemotherapy can be used as a remedy for patients with invasive bladder cancer after TURBT.Combination of TURBT and arterial chemotherapy can be used as a choice for patients who want to keep the bladder and refuse the radical resection of bladder cancer.