不同疗程含呋喃唑酮三联疗法治疗幽门螺杆菌阳性十二指肠溃疡的效果比较

Comparison of efficacy of different therapeutic course of triple therapy with Furazolidone in the treatment of duodenal ulcer with positive Helicobacter Pylori infection

目的比较不同疗程含呋喃唑酮三联疗法治疗幽门螺杆菌阳性十二指肠溃疡的效果。方法选取2012年12月~2016年12月我院收治的幽门螺杆菌阳性十二指肠溃疡患者120例,随机分为甲、乙、丙三组,每组40例。甲组采用呋喃唑酮、阿莫西林、埃索美拉唑三联7 d疗法进行治疗;乙组采用呋喃唑酮、阿莫西林、埃索美拉唑三联10 d疗法进行治疗;丙组采用呋喃唑酮、阿莫西林、埃索美拉唑三联14 d疗法进行治疗。对比三组药物治疗后14C-尿素呼气试验结果彻底转阴率、药物治疗总有效率、用药期间的不良反应发生率。结果丙组患者药物治疗后14C-尿素呼气试验结果彻底转阴率为92.5%,高于甲组和乙组的65.0%和70.0%,差异有统计学意义(P<0.05);丙组治疗总有效率为92.5%,高于甲组和乙组的67.5%和70.0%,差异有统计学意义(P<0.05);用药期间仅有2例(5.0%)出现不良反应,少于甲组和乙组的8例(20.0%)和7例(17.5%),差异有统计学意义(P<0.05)。结论采用呋喃唑酮、阿莫西林、埃索美拉唑三联14 d疗法治疗,可有效提高幽门螺杆菌清除率,具有较高的有效率。

Objective To compare the efficacy of different therapeutic course of triple therapy with Furazolidone in the treatment of duodenal ulcer with positive Helicobacter Pylori infection.Methods Altogether 120 patients with duodenal ulcer with positive Helicobacter Pylori infection from December 2012 to December 2016 in our hospital were selected and randomly divided into three groups（Group A,B and C）,with 40 cases in each group.Group A was treated with triple therapy with Furazolidone,Amoxicillin and Esomeprazole for 7 days;Group B was treated with triple therapy with Furazolidone,Amoxicillin and Esomeprazole for 10 days;Group C was treated with triple therapy with Furazolidone,Amoxicillin and Esomeprazole for 14 days.The number of complete negative cases according to post-medication14C-UBT（14CUrea Breath Test） results,total effective rate of medication and the number of adverse reactions during the medication period were compared among the three groups.Results According to post-medication14C-UBT results,the total negative conversion rate of group C was 92.5%,higher than that of group A and group B（65.0% and 70.0%）,with statistically significant difference between the two groups（P〈0.05）;the total effective rate of medication for duodenal ulcer with positive Helicobacter Pylori infection of group C was 92.5%,higher than that of group A and group B（67.5% and70.0%）,with statistically significant difference between the two groups（P〈0.05）;only 2 cases（5.0%） in group C had adverse reactions during the treatment,less than 8 cases（20.0%） in group A and 7 cases（17.5%） in group B,with statistically significant difference between the two groups（P〈0.05）.Conclusion Application of 14-day triple therapy with Furazolidone,Amoxicillin and Esomeprazole in the treatment of duodenal ulcer with positive Helicobacter Pylori infection can effectively improve the Helicobacter Pylori clearance rate,has higher total efficiency of treatment.