甘露消毒丹联合恩替卡韦治疗慢性乙肝病毒性肝炎的效果观察

Effect observation of Detoxification Pill combined with Entecavir treating chronic hepatitis B

目的探讨甘露消毒丹联合恩替卡韦治疗慢性乙肝病毒性肝炎的临床效果。方法将2015年3月~2016年8月我院收治的48例慢性乙肝病毒性肝炎患者随机分为观察组(24例)和对照组(24例)。对照组对症治疗并给予恩替卡韦0.5 mg进行治疗,观察组在对照组基础上配以甘露消毒丹进行治疗。两组均以12周为1个疗程,共治疗3个疗程。比较两组治疗前后肝功能、纤维化指标,并比较两组的治疗效果。结果观察组治疗后的肝功能指标(ALT、Alb、AST和TBil)及血清肝纤维化指标(透明质酸、层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原)均明显好于对照组,差异有统计学意义(P<0.05)。观察组的总有效率(95.83%)明显高于对照组(87.50%),差异有统计学意义(P<0.05)。结论甘露消毒丹联合恩替卡韦治疗慢性乙肝病毒性肝炎能明显改善肝功能,明显提高抗肝纤维化的疗效,临床效果显著,值得推广。

Objective To investigate the clinical effect of Detoxification Pill combined with Entecavir treating chronic hepatitis B.Methods 48 patients with chronic hepatitis B treated in our hospital from March 2015 to April 2016 were randomly divided into the observation group（24 cases） and the control group（24 cases）.The control group was given symptomatic treatment and treated with 0.5 mg Entecavir,while the observation group was treated with Detoxification Pill on the basis of the control group,the two groups were treated with 12 weeks for 1 course,and patients were treated 3courses of treatment.The liver function and fibrosis indexes between the two groups were compared before and after treatment,and the clinical efficacy between the two groups was compared.Results The liver function indexes after treatment in the observation group（ALT,Alb,AST and TBil） and serum liver fibrosis indexes（hyaluronic acid,laminin,collagen Ⅲ and collagen Ⅳ） were significantly better than those of the control group,and the difference was statistically significant（P〈0.05）.The total effective rate of the observation group（95.83%） was significantly higher than the control group（87.50%）,the difference was statistically significant（P〈0.05）.Conclusion Detoxification Pill combined with Entecavir treating chronic hepatitis B can significantly improve liver function and markedly improve the curative effect of anti liver fibrosis,and the clinical effect is remarkable.It is worthy of promotion.