探讨磁共振扩散加权成像评价肝癌介入术后疗效研究

Effect of MR Diffusion-weighted Imaging in the Evaluation of the Efficacy of Hepatocellular Carcinoma after Intervention ： A Clinical and Animal Study

目的研究探讨磁共振扩散加权成像评价肝癌介入术后疗效 .方法 将 本 院 2 0 1 3年 5 月- 2 0 1 6年 4 月收治的肝 癌患者 31例作为研究对象,另抽取 3 只试验白兔（新西兰）行 V X 2肝内肿瘤建模;患者与动物均通过磁共振扩散加权成像 技术检测.结果 31例患者均通过肝癌介入术治疗,其中 1 1 例患者因后期疗效不理想,于术后 3 个月之内死亡,另 有 2 0例 恢复效果良好;本次研究中 1 只实验白兔在介入手术 2 周内死亡,余 下 2 只介入术后存活 3 5 d以上;而通过对死亡者与存活 者治疗前后磁共振扩散加权成像检测发现,存活者术后 ADC值明显高于术前,而死亡患者手术治疗前后 ADC值并无明显 差异性,甚至略低于术前水平.结论磁共振才广散加权成像技术可有效帮助临床医师评估肝脏肿瘤介入手术疗效.

Objective To investigate the efficacy of MR diffusion-weighted imaging in the evaluation of liver canc-er. Methods A total of 31 patients with hepatocellular carcinoma were enrolled in this study from May 2013 to April 2016. Three New Zealand rabbits were selected for VX2 intrahepatic tumor model. All subjects and animals were treated with MR diffusion-weighted imaging. Results All subjects were treated by hepatocellular carcinoma intervention, 11 cases with poor therapeutic effect and died within 3 months. 20 cases recovered well. One rabbit died within 2 weeks after intervention, and two rabbits survived more than 35 days. MR diffusion-weighted imaging showed that the ADC of survivors was significantly higher than that before operation, while there was no significant difference in ADC value of dead patients before and after the operation. Conclusion MR diffusion-weighted imaging helps clinicians to assess the efficacy of liver cancer intervention.