精索静脉曲张致不育机制的研究进展

A review: the mechanism of male sterility caused by varicocele

精索静脉曲张(VC)是引起男性不育的常见病因,长时间及程度重的VC可以引起睾丸组织细胞损害,导致生精细胞本身及生精坏境的破坏,造成精子质和量的改变,从而造成不育。但VC引起不育的确切机制目前尚不清楚。其机制有很多假说,该文对近年来炎症、氧化应激、凋亡、血睾屏障和免疫异常、内分泌变化、血管活性物质毒性作用、相关分子变化等与不育关系的研究进展,进行了综述。

Varicocele（VC） is the most common cause of male infertility. However,the mechanism of infertility caused by VC has not been fully understood. Long disease course and heavy VC can cause cell damage in the testis,which lead to the destruction of the cell it-self and the environment of the sperm,the change of the quality and quantity of sperm. VC-induced male infertility research put forward a series of theories. This paper mainly summarizes VC from the inflammation and oxidative stress,apoptosis,blood testosterone barrier and immune abnormalities,endocrine changes,vasoactive substances toxicity,related molecular changes.