失神经骨骼肌萎缩的机制及康复治疗

Research progress in mechanisms and rehabilitation of denervated skeletal muscle atrophy

周围神经损伤后,骨骼肌失神经支配将不可避免的发生萎缩,失神经骨骼肌萎缩的发生使得神经修复后的功能恢复仍难以令人满意。因此,揭示失神经肌萎缩的机制,探索失神经支配骨骼肌萎缩的防治方法,一直是周围神经领域内神经修复和康复治疗的研究热点。该文对近年来失神经骨骼肌萎缩的机制及康复治疗的研究进展作一综述。

After peripheral nerve injury,the skeletal muscle is denervated and then inevitably atrophy occurs. Neural functional recovery is still not satisfactory because of the occurrence of muscle atrophy. Therefore,the explorations of mechanism,prevention and treatment of denervated skeletal muscle atrophy are the research focus in the field of peripheral nerve repair and rehabilitation. The mechanism of denervated skeletal muscle atrophy and the progress of rehabilitation therapy in recent years are reviewed.