艾滋病相关口腔上颚卡波西肉瘤的两种治疗方法疗效比较

Comparison of two therapeutic methods for AIDS-related Kaposi's sarcoma in oral cavity

目的探讨两种治疗方案对于口腔上颚艾滋病相关型卡波西肉瘤(AIDS-KS)的临床疗效。方法 50例口腔上颚AIDSKS患者作为诊疗对象,根据临床表现、免疫组化及组织切片病理分析结果诊断口腔上颚AIDS-KS;将50例患者分为A组(齐多夫定或替诺福韦+拉米夫定+克力兹组)、B组(齐多夫定或替诺福韦+拉米夫定+克力兹联合化疗组),A组27例,B组23例,对比两组口腔上颚AIDS-KS患者的治疗效果。结果 A组的有效率为62.96%,B组为78.26%,两组有效率差异较明显。结论对于口腔上颚AIDS-KS患者,应明确临床特点,运用合理的诊断方法;齐多夫定或替诺福韦+拉米夫定+克力兹联合化疗方案治疗AIDS-KS的临床疗效优于多夫定或替诺福韦+拉米夫定+克力兹治疗方案。

Objective To evaluate the clinical efficacy of two therapeutic regimens for AIDS-associated Kaposi′s sarcoma （AIDS-KS）. Methods Fifty patients with AIDS-KS were treated in Department of Infections,the Fourth People′s Hospital of Nanning from May 2011 toAugust 2016,according to the clinical manifestations,immunohistochemistry and pathologic analysis of tissue sections,50 cases were diagnosed as AIDS-KS,whichwere assigned into Group A（Zidovudine or tenofovir plus lamivudine plus clozapine） and Group B （Zidovudine or tenofovir plus lamivudine plus clozapine,combined with chemotherapy）,with 27 patients in group A and 23 in group B. Results The effective rate of group A was 62. 96% and group B was 78. 26% . The difference between the two groups was significant. Conclusions The diagnosis of AIDS-KS in oral maxillofacial palpation should be based on clinical features and rational diagnosis. The combination of dofovir or tenofovir plus lamivudine plus clotz combined with chemotherapy was superior to doxovir plus lamivudine and clofibrate in the treatment of AIDS-KS.