齐拉西酮联合改良电抽搐治疗女性精神分裂症的疗效及对患者认知功能的影响

Effects of Ziprasidone combined with modified electroconvulsive therapy on cognitive function in female patients with schizophrenia

目的:探讨齐拉西酮联合改良电抽搐治疗女性精神分裂症患者的疗效及对认知功能的影响。方法:选取87例女性精神分裂症患者进行分析,随机将其分为对照组(43例)和研究组(44例),对照组患者采用齐拉西酮治疗,研究组患者采用齐拉西酮联合改良电抽搐治疗,并比较两组患者临床治疗效果及对认知功能影响情况。结果:治疗12周后,与对照组比较,研究组患者临床治疗总有效率明显提高,而体重增加值明显降低,两者比较差异有统计学意义(P<0.05);研究组患者治疗后,其个人与社会功能量表(PSP)评分、韦氏成人智力量表(WAIS-RC)评分优于对照组,两者比较差异有统计学意义(P<0.05)。结论:齐拉西酮联合改良电抽搐疗法治疗女性精神分裂症患者的临床效果优于单纯齐拉西酮治疗效果,且未对认知功能造成明显影响。

Objective： To investigate effects of Ziprasidone combined with modified electroconvulsive therapy on cognitive function in female patients with schizophrenia. Methods： 87 cases of female patients with schizophrenia were analyzed and were randomly divided into control group（ 43 cases） and study group（ 44 cases）. The control group was treated with Ziprasidone,while the study group was treated with Ziprasidone combined with modified electroconvulsive therapy. The clinical curative effects and the effects of the treatment on the cognitive function of the two groups were compared. Results： 12 weeks after the treatment,compared with the control group,the total effective rate of the study group significantly increased,while the weight gain decreased significantly,and the differences between the two group were statistically significant（ P〈0.05）. After the treatment,the scores of personal and social function scale（ PSP） and Wechsler adult intelligence scale（ WAIS-RC） of the study group were better than those of the control group,and the differences between the two group were statistically significant（ P〈0.05）. Conclusions： Ziprasidone combined with modified electroconvulsive therapy in the treatment of the female patients with schizophrenia is more effective than single Ziprasidone and has significant effects on their cognitive function.