奥氮平联合氟西汀治疗抑郁症的疗效和不良反应探究

Investigation of Curative Effect and Adverse Reactions of Olanzapine Combined with Fluoxetine in the Treatment of Depression

目的对抑郁症治疗中联用奥氮平、氟西汀的效果与不良反应出现情况进行探讨。方法方便选取2016年1月—2017年1月间68例于该院接受治疗的抑郁症患者随机分为两组,32例单独以氟西汀展开治疗为单药组,36例以氟西汀、奥氮平联用的方案展开治疗为联药组,对照两组疗效、安全性。结果治疗后,联药组HAMD、HAMA评分明显比单药组低,联药组实现了94.44%的总有效率,与单药组的75.00%对照明显较高,差异有统计学意义(P<0.05);两组分别有13.89%、12.50%出现不良反应,对比差异无统计学意义(P>0.05)。结论对于抑郁症患者的治疗,于氟西汀治疗基础上给予奥氮平可使疗效提升,但不会使不良反应有明显增加,可积极对此治疗方案进行应用。

Objective This paper tries to discuss the effect and adverse reaction of olanzapine and fluoxetine in treatment of depression. Methods 68 patients with depression treated in this hospital from January 2016 to January 2017 were convenient selected and divided into two groups, 32 cases treated with fluoxetine alone for single drug group, 36 cases with fluoxetine and olanzapine for the combination medicine group, the efficacy and safety of the two groups were compared. Results After treatment, HAMD, HAMA scores in combination medicine group were obviously lower than the single drug group,whose total effective rate 94.44%, significantly higher than that of the single drug group of 75.00%（P0.05）; The adverse reactions of the two groups were 13.89% and 12.50%, with no significant difference（P0.05）. Conclusion Olanzapine combined with fluoxetine treatment for patients with depression can increase the curative effect, not increases adverse reactions.This method can be positively applied in the treatment.