贝那普利联合百令胶囊治疗慢性肾炎的疗效评价

Evaluation of the Curative Effect of Benazepril Combined with Bailing Capsule on Chronic Nephritis Patients

目的探讨对慢性肾炎患者给予百令胶囊、贝那普利联合治疗的临床疗效。方法方便选取该院2016年2月—2017年2月收治的160例慢性肾炎患者进行观察,所有患者均给予饮食指导、血压控制等对症治疗。采用随机分组法分为研究组、对照组,每组中80例。研究组给予百令胶囊、贝那普利联合治疗,对照组给予贝那普利治疗。治疗3个疗程,记录两组患者的肾功能指标变化情况及总有效率。结果治疗后,研究组24 h尿蛋白定量(0.6±0.5)g明显低于对照组(1.2±0.6)g,差异有统计学意义(P<0.05);研究组血肌酐(Scr)、血尿素氮(BUN)水平分别为(96.9±24.6)μmol/L、(5.5±0.8)mmol/L,对照组血肌酐(Scr)、血尿素氮(BUN)水平分别为(94.1±23.1)μmol/L、(5.3±1.0)mmol/L,差异无统计学意义(P>0.05);研究组总有效率(92.50%)明显优于对照组(80.00%),差异有统计学意义(P<0.05)。结论对慢性肾炎患者给予百令胶囊、贝那普利联合治疗可以迅速降低尿蛋白水平,治疗效果显著,具有较高的临床应用价值。

Objective This paper tries to investigate the curative effect of benazepril combined with bailing capsule in the treatment of chronic nephritis patients. Methods 160 cases of chronic nephritis patients in this hospital from February 2016 to February 2017 were conveniently selected and given the symptomatic treatment, such as dietary guidance, blood pressure control and so on, and were randomly divided into the study group and the control group, with 80 cases in each group. The study group was given bailing capsule combined with benazepril treatment, the control group was given the benazepril treatment, and the treatment lasted for 3 courses, the changes of renal function and the total efficiency in the two groups were recorded. Results After treatment, the 24 h urine protein quantification in the study group was（0.6±0.5）g, significantly lower than that in the control group of（1.2±0.6）g, and the difference was statistically significant（P〈0.05）; the serum creatinine（Scr）, blood urea nitrogen（BUN） in the study group was（96.9±24.6）μmol/L,（5.5±0.8）mmol/L, the serum creatinine（Scr）, blood urea nitrogen（BUN） in the study group was（96.9±24.6）μmol/L,（5.3±1.0）mmol/L, there was no statistically significant difference in the two groups（P 〉0.05）; the total efficiency in the study group was 92.50%, significantly better than the control group of 80.00%, the difference was statistically significant（P 〈0.05）. Conclusion For Chronic nephritis patients, bailing capsule combined with the benazepril can rapidly decrease the levels of urinary protein, the treatment effect is remarkable,which has high clinical value.