一种基于丹磺酰胺染料的高选择性汞(Ⅱ)离子荧光探针（英文）

A Highly Selective Mercury Ion (Ⅱ) Fluorescent Probe Based on Dansyl Dye

对人类健康和社会环境而言,汞离子被认为是毒性最大的金属离子之一。本文设计、合成了一种新型基于丹磺酰胺染料的荧光探针,并研究了其对金属阳离子的识别性质。研究结果表明:该荧光探针在水溶液中,对汞离子具有高度的选择性和良好的灵敏度,且不受其它金属阳离子的干扰。该探针对汞离子的检测限可以达到2.1×10-8 mol/L。该探针极低的检测限和良好的水溶性表明其可用于活细胞中检测汞离子。生物成像实验证实该探针具有良好的细胞膜透性和生物相容性。

Mercury ion （Ⅱ） is known as one of the most toxic metal ions both for humans and the environment.In this work,a new fluorescent probe based on dansyl dye was designed and synthesized,and its determining property towards metal cations was investigated.The result indicated that this dansyl-based fluorescent probe possessed high selectivity and good sensitivity towards mercury ion （Ⅱ]）in an aqueous media without any interference from other metal cations.It was worth mentioning that the detection limit of mercury ion （Ⅱ） can reach to 2.1 ×10^-8 mol/L.Such low detection limit and good water-solubility supported this probe could be used to visualize the level of mercury ion （Ⅱ） in living cells.Furthermore,the bioimaging experiment confirmed that this probe had good membrane permeability and biocompatibility.