运动与饮食综合干预对肥胖儿童脂质代谢、胰岛素敏感性及微炎症状态的影响

Effect of exercise and dietary intervention on lipid metabolism,insulin sensitivity and microinflammatory state in obese children

目的:研究运动与饮食综合干预对肥胖儿童脂质代谢、胰岛素敏感性及微炎症状态的影响。方法:选择2014年5月~2016年12月期间在自贡市第三人民医院诊断为肥胖的156儿童作为研究对象,随机分为接受运动与饮食综合干预的干预组及不进行特别干预的对照组。入组前及入组后5、10周时,检测血清中脂肪细胞因子及炎症反应指标的含量,评估胰岛素敏感性。结果:干预组患者入组后5、10周时血清中Leptin、Chemerin、肿瘤坏死因子(TNF)-α、白介素(IL)-6、超敏C反应蛋白(hs-CRP)、MCP-1、血管细胞黏附分子(VCAM)-1、细胞间黏附分子(ICAM)-1的含量以及空腹血糖(FBG)、F-Ins的水平均显著低于入组前,Adiponectin、Vaspin的含量均显著高于入组前;对照组患者入组后5、10周时血清中Leptin、Chemerin、Adiponectin、Vaspin、TNF-α、IL-6、hs-CRP、MCP-1、VCAM-1、ICAM-1的含量以及FBG、F-Ins的水平与入组前比较无差异。结论:运动与饮食综合干预能够改善肥胖儿童的脂质代谢、胰岛素敏感性及微炎症状态。

Objective：To study the effect of exercise and dietary intervention on lipid metabolism,insulin sensitivity and microinflammatory state in obese children.Methods：A total of 156 children who were diagnosed with obesity in Zigong Third People＇s Hospital between May 2014 and December 2016 were selected as research subjects and randomly divided into the intervention group who received exercise and dietary comprehensive intervention and the control group who received no special intervention.Before enrollment as well as 5weeks and 10 weeks after enrollment,the serum contents of adipocytokines and inflammatory response indicators were detected,and the insulin sensitivity was assessed.Results：Serum leptin,chemerin,TNF-α,IL-6,hs-CRP,MCP-1,VCAM-1and ICAM-1contents as well as FBG and F-Ins levels of intervention group 5weeks and 10 weeks after enrollment were significantly lower than those before enrollment while adiponectin and vaspin contents were significantly higher than those before enrollment;serum leptin,chemerin,adiponectin,vaspin,TNF-α,IL-6,hs-CRP,MCP-1,VCAM-1and ICAM-1contents as well as FBG and F-Ins levels of control group 5weeks and 10 weeks after enrollment were not different from those before enrollment.Conclusion：Comprehensive exercise and dietary intervention can improve the lipid metabolism,insulin sensitivity and microinflammatory state in obese children.