支气管动脉化疗栓塞与放射性粒子植入联合治疗对局部晚期非小细胞肺癌肿瘤标志物和T细胞亚群的影响

Effects of combined treatment of bronchial arterial chemoembolization and radioactive particle implantation on tumor markers and T lymphocyte subsets in locally advanced non-small cell lung cancer

目的:探讨支气管动脉化疗栓塞联合放射性粒子植入治疗局部晚期非小细胞肺癌,对患者血清肿瘤标志物及T细胞亚群水平的影响。方法:91例局部晚期非小细胞肺癌患者依据随机数据表法分为对照组(n=45)和观察组(n=46),对照组患者给予支气管动脉化疗栓塞术治疗,观察组患者在对照组基础上给予放射性粒子植入治疗,比较治疗前后患者血清肿瘤标志物及T细胞亚群水平。结果:治疗前,观察组的CEA、NSE、CA125、CD4+、CD8+、CD4+/CD8+和NK细胞水平与对照组相比,无统计学差异(P>0.05)。与组内治疗前相比,两组治疗后的CEA、NSE、CA125及CD8+水平均显著降低(P<0.05),且治疗后观察组水平显著低于对照组,比较有统计学差异(P<0.05);与组内治疗前相比,两组治疗后的CD4+、CD4+/CD8+和NK水平均显著升高(P<0.05),且观察组水平显著高于对照组,差异有统计学意义(P<0.05)。结论:支气管动脉化疗栓塞联合放射性粒子植入可有效降低局部晚期非小细胞肺癌患者的血清肿瘤标志物水平,改善患者的T细胞亚群水平,具有重要的临床价值。

Objective：To investigate the effects of bronchial arterial chemoembolization combined with radioactive particle implantation on the level of serum tumor markers and T lymphocyte subsets in patients with locally advanced non-small cell lung cancer.Methods：A total of 91 patients with locally advanced non-small cell lung cancer were divided into the control group（n=45）and observation group（n=46）according to the random data table.Patients in the control group was treated with bronchial arterial chemoembolization,based on the treatment of the control group,patients in the observation group were treated with radioactive particle implantation,the serum tumor markers and the levels of T lymphocyte subsets of the two groups were compared before and after treatment.Results：The levels of CEA,NSE,CA125,CD4＋,CD8＋,CD4＋/CD8＋and NK in the two groups before the treatment were not statistically significant（P0.05）.Compared with the group before treatment,levels of CEA,NSE,CA125 and CD8＋of the two groups after treatment were significantly decreased（P0.05）,and these levels in the observation group after treatment were significantly lower than that of the control group（P0.05）;Compared with the group before treatment,the levels of CD4＋,CD4＋/CD8＋and NK in the two groups after treatment were significantly increased（P0.05）,and these levels in the observation group were significantly higher than that of the control group（P0.05）.Conclusion：Bronchial artery embolization combined with radioactive particle implantation can effectively reduce the serum tumor markers level for locally advanced non-small cell lung cancer,improve the level of T cell subsets of patients,and it has important clinical value.