三维有限元模型分析对骨质疏松患者股骨头骨密度及骨代谢活力的评估价值

The evaluation value of three-dimensional finite element model analysis for bone mineral density and bone metabolism activity in patients with osteoporosis

目的:探讨三维有限元模型分析对骨质疏松患者股骨头骨密度(BMD)及骨代谢活力的评估价值。方法:收集在本院确诊的骨质疏松患者218例作为观察组,另取同期在本院进行体检的健康志愿者100例作为正常对照组。对两组研究对象的股骨头进行三维有限元模型分析,同时测定股骨头BMD水平、血清骨代谢指标含量。采用Pearson检验判断股骨头三维有限元模型分析对骨质疏松病情的评估价值。结果:观察组的松质骨、皮质骨Von Mises应力值低于正常对照组,观察组股骨颈的BMD值低于正常对照组;血清中骨代谢指标BGP的含量低于正常对照组,NBAP、TRACP-5b、CTX-1的含量高于正常对照组(P<0.05)。经Pearson检验发现,骨质疏松患者股骨头松质骨、皮质骨Von Mises应力值与BMD值、骨代谢指标含量直接相关。结论:骨质疏松患者的三维有限元模型分析结果可客观反映股骨头BMD值、骨代谢活力,是评估患者远期骨折风险的可靠方式。

Objective：To study the evaluation value of three-dimensional finite element model analysis for bone mineral density（BMD）and bone metabolism activity in patients with osteoporosis.Methods：A total of 218 patients who were diagnosed with osteoporosis in the hospital were collected as observation group,and 100 healthy volunteers who received physical examination in the hospital during the same period were selected as normal control group.The femoral head of the two groups was analyzed by three-dimensional finite element model,and the femoral head BMD levels and serum bone metabolism index contents were measured.Pearson test was used to evaluate the evaluation value of femoral head three-dimensional finite element model for osteoporosis.Results：The cancellous bone and cortical bone Von Mises stress value of observation group were lower than those of normal control group,and femoral neck BMD value of observation group was lower than that of normal control group;serum bone metabolism index BGP content was lower than that of normal control group while NBAP,TRACP-5band CTX-1contents were higher than those of normal control group（P〈0.05）.Pearson test showed that the cancellous bone and cortical bone Von Mises stress value of patients with osteoporosis were directly correlated with BMD value and bone metabolism index contents.Conclusion：The three-dimensional finite element model analysis results of patients with osteoporosis can objectively reflect the femoral head BMD value and bone metabolism activity,and is a reliable way to evaluate the risk of longterm fractures.