集体心理干预对精神分裂症患者氧化应激、细胞凋亡及炎症反应的影响

Effect of group psychological intervention on oxidative stress,apoptosis and inflammatory response in patients with schizophrenia

目的:探讨集体心理干预对精神分裂症患者氧化应激、细胞凋亡及炎症反应的影响。方法:收集在本院接受住院治疗的精神分裂症患者80例,随机分为对照组、观察组各40例。对照组接受临床常规干预,观察组患者在常规干预基础上加入集体心理干预,对比两组干预前后血清中氧化应激指标、凋亡分子、炎症因子含量的差异。结果:干预前,两组血清中氧化应激指标、凋亡分子、炎症因子含量的差异无统计学意义(P>0.05)。干预后,两组血清中SOD、bcl-2的含量均高于干预前,MDA、bax、Caspace-3、Fas、IL-1β、IL-6、TNF-α的含量均低于干预前且观察组患者血清中SOD、bcl-2的含量均高于对照组,MDA、bax、Caspace-3、Fas、IL-1β、IL-6、TNF-α的含量均低于对照组。结论:集体心理干预用于精神分裂症患者能够有效抑制全身氧化应激及炎症反应,减轻细胞凋亡进程。

Objective：To investigate the effect of group psychological intervention on oxidative stress,apoptosis and inflammatory response in patients with schizophrenia.Methods：A total of 80 patients with schizophrenia who received hospitalization in the hospital between September 2014 and October 2016 were collected and divided into control group（n=40）and observation group（n=40）according to the random number table method.Control group received routine clinical intervention while observation group received group psychological intervention on the basis of conventional intervention.The differences in serum contents of oxidative stress indicators,apoptosis molecules and inflammatory factors were compared between the two groups of patients before and after intervention.Results：Before intervention,the differences in serum levels of oxidative stress indexes,apoptosis molecules and inflammatory factors were not statistically significant between the two groups of patients（P〉0.05）.After intervention,serum SOD and bcl-2levels of both groups of patients were higher than those before intervention while MDA,bax,Caspace-3,Fas,IL-1β,IL-6and TNF-αlevels were lower than those before intervention,and serum SOD and bcl-2levels in observation group were higher than those in control group while MDA,bax,Caspace-3,Fas,IL-1β,IL-6and TNF-αlevels were lower than those in control group.Conclusions：Group psychological intervention can effectively inhibit the systemic oxidative stress and inflammatory response,and reduce the process of apoptosis in patients with schizophrenia.