癌症干细胞特性及靶向治疗进展

Progress on cancer stem cell features and targeted treatment

癌症干细胞因其自我更新和治疗抵抗等特性被认为是癌症发生、发展、耐药和复发的根本原因.癌症干细胞的干性调控和耐药性机制研究受到越来越广泛的关注,同时一系列新研究证明了癌症干细胞群体并非过去所认为的单一不变的群体,而是具有多样性和可塑性.这一概念丰富了对癌症干细胞的认识,为治疗方案的研究提供了新的方法.本文将总结癌症干细胞的重要特性,以及近年来基于干性调控通路开发的靶向治疗临床试验中的成果和问题,展望其应用前景.

Cancer stem cells were thought to be responsible for the tumor initiation, progression, drug resistance and relapse because of their abilities of self-renewal and treatment resistance.There are more and more studies focus on their regulation mechanism of self-renewal and drug-resistance,and a series of studies showed that the cancer stem cell population may not be a single stasis population but they are diverse and malleable. This notion enriches the knowledge of cancer stem cells,can provide new approaches for the development of treatment. The current review summarized the key features of cancer stem cells,the results and problems of clinical trial through targeted treatment based on the interfering of stemness regulation pathways,and discussed the prospects of cancer stem cells.