HGSC输卵管起源学说的研究进展

Progress on the theory of fallopian tube as the origin of high-grade serous carcinoma

低分化浆液性卵巢癌(HGSC)是上皮性卵巢癌(EOC)的主要分型,其病死率居妇科恶性肿瘤首位.早期EOC几乎没有症状,故目前尚缺乏有效的早期诊断手段,而晚期治疗效果又远不及早期,因此,早期筛查和诊断可以有效提高患者的生存率.然而,关于卵巢癌的起源问题,现仍存在争议.最初的观点认为EOC起源于卵巢表面上皮,然而发展至今,人们普遍认同输卵管起源学说.后者认为输卵管癌细胞脱落后植入在卵巢上引发卵巢癌,且输卵管可以作为子宫内膜炎症细胞因子、病原体及刺激物进入卵巢和腹腔的通道,由此增加这些组织癌变的几率.

High-grade serous carcinoma（ HGSC） is the main type of epithelial ovarian cancer（ EOC） and the leading cause of gynecological malignant tumor mortality. As there are few symptoms in the early stage of EOC,there is no effective early diagnosis method,and the effect of late treatment is far less than that of early stage. Therefore,early screening and diagnosis can effectively improve the survival rate of patients. However,the origin of ovarian cancer remains controversial. The initial view believed that EOC originated in the epithelial surface of the ovary,but in nowadays,it is generally agreed that epithelial ovarian cancer originated in fallopian tube. The latter idea believes that ovarian cancer is caused by the plant of fallopian tube cancer cells,and the fallopian tube can be used as a channel for the cytokine,pathogen and stimulator of endometritis to enter the ovary and abdominal cavity,which can increase the chance of cancerization of those tissues.