口腔鳞状细胞癌早期诊断标志物的研究进展

Advances in research on early diagnostic markers of oral squamous cell carcinoma

口腔鳞状细胞癌(OSCC)是额面部最常见的肿瘤,早期诊断标志物的研究有利于其诊断.通过对近期OSCC早期诊断物质相关的文献进行检索和回顾,总结了OSCC早期诊断标志物的研究进展.研究表明,SOX2和TERC基因的扩增,MMP-9以及microRNA的异常表达,编码TFPI-2的基因启动子甲基化,IL-2、IL-6、IL-8、TNF-α、Cyfra 21-1、ZNF510、白细胞介素受体拮抗剂、ATP6V1C1等蛋白质以及机体内的一些其他物质的异常表达与OSCC的发生发展密切相关.OSCC早期诊断标志物的研究对其治疗以及判断预后有着重要作用.

Oral squamous cell carcinoma（ OSCC） is the most common tumor in the forehead and face and research on its early diagnostic indicators is beneficial for its treatment. The paper summarizes the literatures related to the indicators and research progress of OSCC. The studies have shown that OSCC is closely related to SOX2 and TERC gene amplification,abnormal expression of microRNAs and MMP-9,promoter methylation of genes encoding TFPI-2,and IL-2,IL-6,IL-8,TNF-α,Cyfra 21-1,ZNF510,ATP6V1C1 hormone receptor antagonist agent of protein and some other abnormal expressions in the body. Research on the early diagnostic indicators plays an important role in the treatment and prognosis of OSCC.