晚期胃癌的转化治疗

Conversion therapy of advanced gastric cancer

有30％-40％的进展期胃癌患者在初诊时即失去了根治性手术的机会，故化疗成为其主要的治疗手段，但总体预后欠佳。近年来。多项二期临床试验研究结果显示，针对此类患者，转化治疗前景可观。转化治疗即通过多学科诊疗（MDT）模式．结合化疗、放疗及靶向治疗等综合治疗手段，使初始不可切除的肿瘤转化为可根治性切除，从而延长患者的生存期和提高其生活质量。

There are 30% to 40% of advanced gastric cancer patients who lose the opportunity of curative surgery at initial diagnosis, so chemotherapy is recommended as the main treatment modality, however, the overall prognosis is poor. Recently, a number of phase Ⅱ studies show an enormously ideal potential of conversion therapy in these patients. Conversion therapy uses rational chemotherapy, radiotherapy and targeted therapy and so on combined with MDT assessment to translate initial unresectable case to resectable one, which obviously prolongs survival time and improves quality of life. In this review, we address the indications, development and our experiences of conversion therapy in advanced GC, which looks forward to providing the reference to clinical diagnosis and treatment.