微流控技术在纳米药物输送系统中的应用

Applications of microfluidic technology to delivery of nanoparticulate drug

微流控是利用微纳米级尺度的管道来处理和操控流体所涉及的一门技术。利用微流控精准控制层流液体或液滴混合效应可实现传统常规液体混合方法难以完成的纳米粒制备。本文以纳米药物输送领域的研究进展为切入点,主要介绍微流控技术在脂质体、聚合物纳米粒和杂化纳米粒等纳米粒药物输送系统构建中的应用,并剖析其在不同结构的纳米组装体精准控制作用机制。本综述将为纳米药物输送系统领域的研究者如何更科学合理地利用微流控技术提供借鉴参考。

Microfluidics is a technology that involves the use of micro-nanoscale pipelines to manipulate fluid mixing. Precise control of the mixing process of laminar flows or liquid droplets by using microfluidics will contribute to the preparation of nanoparticles, which are difficult to be achieved by the conventional methods. Based on the progress in delivery systems of nanoparticulate drug, we provide a summary to introduce the applications of microfluidics in construction of nanoparticulate drug delivery system such as liposomes, polymer nanoparticles and hybrid nanoparticles, and analyze the assembling mechanisms of different nanostructures by using microfluidic precise control. This review will provide a reference in utilization of microfluidic technology more scientifically and reasonably.