摘要
花青素具有很高的健康益处与生物活性,将其制备成口服液,能使溶液色泽鲜明、性状美观,并易于吸收。然而由于其本身特殊的抗氧化活性,使其易受外界理化因素的影响而发生氧化、聚合和降解等不稳定现象,严重影响产品的稳定性与货架寿命。传统的pH调节、去氧和避光等方法不能满足稳定花青素的需求,添加稳定剂与花青素分子形成复合物以提高其稳定性成为新的有效方案。本文系统梳理了相关学科运用花青素稳定剂的作用原理及应用方法,以期探索中药与天然药物口服溶液澄清稳定的关键技术,为口服液开发和利用花青素稳定剂提供理论支持及技术参考。
Anthocyanins has a high health benefits and biological activity, which can make the solution easily absorbed and has a bright color, beautiful appearance in oral liquid. However, due to its particularity antioxidant activity, it is easy to be affected by the external physical and chemical factors, and then oxidation, polymerization, degradation and other unstable phenomena occurs that seriously affect the stability of products and shelf life. The traditional methods of pH regulation, deoxygenation and light avoidance could not meet the demand of stable anthocyanins. Addition of stabilizer to anthocyanins is a new effective way to improve the stability of anthocyanins. This paper is prepared to summarize systematically the principle and application methods of anthocyanins stabilizers to explore the key technology of clarification and stabilization of traditional Chinese medicine in the natural oral liquid, which may provide theoretical support and technical reference for the development and utilization of anthocyanins stabilizer.
作者
黄浩洲
张定堃
姜红
林俊芝
贺亚男
许润春
杨明
韩丽
HUANG Hao-zhou ZHANG Ding-kun JIANG Hong LIN Jun-zhi HE Ya-nan XU Run-chun YANG Ming HAN Li(Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources Co-founded by Sichuan Province and Ministry of Science and Technology, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Central Laboratory, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China diangxi University of Traditional Chinese Medicine, Nanchang 330004, China)
出处
《药学学报》
CAS
CSCD
北大核心
2017年第10期1524-1532,共9页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81403115)
国家基础科学人才培养基金资助项目(J13100340-19)
成都中医药大学科技发展基金
关键词
花青素
口服液
稳定剂
澄明度
降解
anthocyanins
oral liquid
stabilizer
clarity
degradation