清肺化痰汤对急性支气管扩张患者肺功能及外周血象的影响

Effect of Qingfei Huatan Decoction(清肺化痰汤) on the Levels of WBC,NEU and LYM in Peripheral Blood of Patients with Acute Bronchial Asthma of Phlegm Heat Obstructing the Lung

目的:探讨清肺化痰汤治疗对急性痰热壅肺型支气管扩张患者肺功能及外周血白细胞计数(WBC)、中性粒细胞(NEU)、淋巴细胞(LYM)水平的影响。方法:选取80例急性痰热壅肺型支气管扩张患者,随机分为对照组及治疗组,每组40例。两组予常规西医治疗,治疗组再予清肺化痰汤口服。比较两组治疗前后肺功能、症状积分、外周血(WBC、NEU、LYM)的变化,评估临床疗效。结果:治疗后两组FEV1、FEV1/FVC水平均高于同组治疗前(P<0.01);治疗后治疗组FEV1、FEV1/FVC水平均高于同期对照组(P<0.01)。两组治疗前后LYM水平组内、组间差异均无统计学意义(P>0.05);治疗后两组WBC、NEU水平及咳嗽、咳痰性状等症状积分均低于同组治疗前(P<0.01),治疗后治疗组WBC、NEU水平及咳嗽、咳痰性状等症状积分均低于同期对照组(P<0.01)。总有效率对照组为80.0%,治疗组为97.5%,组间差异有统计学意义(P<0.05)。结论:急性痰热壅肺型支气管扩张采用清肺化痰汤辅助治疗,可进一步改善患者肺功能,改善患者临床症状,稳定外周血WBC、NEU水平。

Objective： To investigate the effect of Qingfei Huatan Decoction （清肺化痰汤, QFHTD） on peripheral blood white blood cell count （WBC）, neutrophil （NEU） and lymphocyte （LYM） in patients with acute bronchial asthma of phlegm heat obstructing the lung. Methods： The 80 patients with bronchial asthma were randomly divided into control group and study group, each group of 40 cases. Two groups were given conventional western medicine; the study group was given QFHTD. The changes of pulmonary function, symptom scores, peripheral blood （WBC, NEU, LYM） before and after treatment in two groups were compared. Results： After treatment, the levels of FEV1 and FEV1/FVC in the two groups were higher than those in the same group before treatment （P〈0.01）. After treatment, the levels of FEV1 and FEV1/FVC in the study group were higher than those in the control group （P〈0.01）. Differences between the two groups before and after treatment LYM levels within and between groups had no statistically significant （P〉0.05）; after treatment, symptoms of the two groups of WBC, NEU and the level of cough and expectoration traits score are lower than the same group before treatment （P〈0.01）, the symptoms after treatment in the study group WBC, NEU and the level of cough and expectoration the integral character was lower than control group （P〈0.01）. The total effective rate is 80% in the control group, the study is 97.5%, the difference is statistically significant between the two groups （P〈0.05）. Conclusion： QFHTD can improve the lung function and the clinical symptoms of patients with acute bronchial asthma of phlegm heat obstructing the lung, and stabilize the levels of WBC and NEU in peripheral blood.