肺部链格孢霉合并曲霉菌感染1例

A case of pulmonary alternariosis complicated with aspergillosis

1例61岁女性肺部链格孢霉合并曲霉菌感染,反复咯血、咳嗽、咳痰3年。真菌培养鉴定为链格孢霉。组织病理活检结果提示肺曲霉病。患者接受伏立康唑400 mg/d静脉滴注治疗7 d后改为两性霉素B 25 mg/d静脉滴注治疗11 d,患者出院时改为伏立康唑口服400 mg/d治疗。目前患者无咯血、咳嗽、咳痰症状,复查肺部CT结果显示正常。

A 61-year-old woman with pulmonary alternariosis and aspergillosis was reported. The patient presented with recurrent hemoptysis and cough for 3 years. Alternaria was identified by fungal culture. Biopsy specimen showed pulmonary aspergillosis. The patient had been treated with voriconazole at 400 mg/d through intravenous guttae for 7 days, and then switched amphotericin B at 25 mg/d through intravenous guttae for 11 days. The patient was treated with voriconazole at 400 mg through oral when she was discharged from hospital. After the treatment, the clinical symptoms of hemoptysis and cough were recovered, and the lung CT examinations showed normal.