慢性淋巴细胞性甲状腺炎的患病因素分析

Risk factors of the chronic lymphocytic thyroiditis

目的通过分析体检中发现的慢性淋巴细胞性甲状腺炎(CLT)患者的环境特征、病史资料等,探讨CLT发病的可能因素。方法以2014年6月~2014年12月在沧州市中心医院进行有关甲状腺项目的 6 325名体检者为研究总体,分析CLT患者的患病率,随机挑选CLT患者80例,另选取同期体检健康者80名,分析CLT患者和健康体检者的性别、遗传、地域差异、体质量指数、城市生活、体力劳动、学历、家庭收入、慢性扁桃体炎等因素特点,进行Logistic统计分析。结果沧州地区的CLT患病率约为6.01%(95%可信区间5.42%~6.59%),经过分析,性别、遗传、地域差异、慢性扁桃体炎等差异有统计学意义(β=-0.867,χ2=4.689,P=0.030),(β=-0.712,χ2=4.140,P=0.042),(β=0.633,χ2=6.392,P=0.011),(β=1.471,χ2=12.931,P=0.000)。结论沧州地区的CLT患病率约为5.42%~6.59%,慢性扁桃体炎、遗传、沿海地带、女性均是CLT发病的危险因素。

Objective To discuss the possible risk factors in the development of chronic lymphocytic thyroiditis. Methods The people who had medical checks about thyroid in Cangzhou central hospital from June to December 2014 were enrolled. Among these people, 80 patients who were diagnosed as chronic lymphocytic thyroiditis were in the observation group, and 80 healthy subjects were in the control group. The factors such as gender,gene,regional differences,body mass index,city life,physical labor,education,family income and chronic tonsillitis were analyzed by logistic analysis. Results The prevalence of chronic lymphocytic thyroiditis was 6.01%（95% confidence interval 5.42%-6.59%）The difference of gender,gene,regional differences,chronic tonsillitis was statistically significant between two groups（β=-0.867,χ^2=4.689,P=0.030）,（β=-0.712,χ^2=4.140,P=0.042）,（β=0.633,χ^2=6.392,P=0.011）,（β=1.471,χ^2=12.931,P=0.000）. Conclusion The prevalence of chronic lymphocytic thyroiditis in Cangzhou city is about5.42% - 6.59%. Recurrent tonsillitis,coastal areas,women,gene are the risk factors of CLT.