同步加量调强放疗联合化疗治疗局部晚期非小细胞肺癌的临床效果

The Clinical Efficacy of Concurrent Intensity Modulated Radiotherapy Combined with Chemotherapy in the Treatment of Locally Advanced Non-small Cell Lung Cancer

目的:观察并评价同步加量调强放疗联合化疗术治疗局部晚期非小细胞肺癌的临床疗效。方法:选取本院2015年1月-2016年5月就诊并由病理或者细胞学分析证实的102例非小细胞肺癌(NSCLC)患者,按照随机数字表法分为对照组和治疗组,每组51例。对照组给予IMRT治疗,治疗组给予SIB-IMRT治疗。比较两组的不良反应发生情况、1年生存率、临床疗效。结果:治疗组的不良发生发生率均低于对照组(P<0.05);治疗组的治疗有效率和疾病控制率均高于对照组(P<0.05);治疗组的1年生存率高于对照组(P<0.05)。结论:针对局部晚期非小细胞肺癌患者,同步加量调强放疗联合化疗术效果良好,降低了不良反应发生率,提高了患者的生存率,可积极应用于临床。

Objective： To observe and evaluate the clinical efficacy of the synchronous dosage of intensity- modulated radiotherapy combined with chemotherapy in the treatment of locally advanced non-small cell lung cancer.Method： A total of 102 NSCLC patients with pathological or cytological analysis confirmed in our hospital from January 2015 to May 2016, they were divided into the treatment group and the control group according to random number table method, 51 cases in each group.The control group was given IMRT, the treatment group was given SIB-IMRT.The occurrence of adverse reaction, the clinical curative effect and one year survival rate of two groups were compared.Result： The occurrence of side effects of the treatment group were lower than the control group （ P〈0.05 ） ; the clinical curative effect and disease control rate of the treatment group were higher than those of the control group （ P〈0.05 ） ; one year survival rate of the treatment group was higher than that of the control group （ P〈0.05 ） .Conclusion： For patients with locally advanced non-small cell lung cancer, the concurrent dose plus intensity-modulated radiotherapy combined with chemotherapy has a good effect, reduces the incidence of adverse reactions, improves the survival rate of patients, and can be actively applied in clinical.