摘要
间充质干细胞(MSCs)是一种多能干细胞,在体外的特定诱导条件下可以分化为多种组织细胞。其独特的生物学特性,在组织损伤修复与肿瘤靶向治疗等临床应用方面展现出广阔的应用前景。然而有研究表明MSCs在应用过程中有可能发生恶性转化。本文主要对MSCs发生恶性转化的影响因素、分子机制以及如何预防MSCs发生恶性转化的新近研究进行综述。
Mesenchymal stromal （stem） cells （MSCs） are pluripotent stem cells to differentiate into various types of cells. This unique characteristic allowed MSCs to be used in cytotherapy, which holds most promising for repair of injured cells/tissues and anti-tumor intervention. However, malignant transformation of MSCs is a major challenge for clinical applications. This review focuses on the recent studies regarding culture conditions, molecular mechanisms, and preventive strategies of malignance of MSCs in practice.
出处
《中华细胞与干细胞杂志（电子版）》
2017年第4期231-236,共6页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
关键词
间质干细胞
细胞转化
肿瘤
Mesenchymal stem cell
Cell transformation, neoplastic
