氯吡格雷联合阿司匹林治疗短暂性脑缺血发作的疗效

Efficacy of clopidogrel combined with aspirin in the treatment of transient ischemic attack

目的探讨氯吡格雷与阿司匹林联合在短暂性脑缺血发作治疗中的疗效。方法选择我院2014年7月至2016年11月收治的120例短暂性脑缺血发作患者进行研究,按照治疗方法将其分为甲组与乙组,每组60例。甲组单纯采用阿司匹林进行治疗,乙组采用氯吡格雷与阿司匹林联合治疗,对比两组患者的临床疗效。结果甲组的临床治疗总有效率为76.67%,低于乙组的95.00%(P<0.05);治疗后,两组患者的血流变学指标水平均降低(P<0.05);乙组低切黏度、高切黏度、血浆黏度、纤维蛋白原水平低于甲组,差异有统计学意义(P<0.05);乙组不良反应发生率明显低于甲组(P<0.05)。结论对短暂性脑缺血发作患者采用氯吡格雷与阿司匹林联合治疗,可有效提高患者的临床效果。

Objective To investigate the efficacy of clopidogrel combined with aspirin in the treatment of transient ischemic attack. Methods One hundred and twenty cases of patients with transient ischemic attack admitted in our hospital from July 2014 to November 2016 were enrolled in this research, and divided into group A and group B according to different treatment methods, with 60 cases in each group. Group A was treated with aspirin alone, while group B was treated with clopidogrel and aspirin, the clinical effects of the two groups were compared. Results The total effective rate of clinical treat- ment in group A was 76.67%, which was lower than 95.00% in group B （P〈0.05）. After treatment, the hemorheology indexes of the two groups significantly decreased （P〈0.05）. The low shear viscosity, high shear viscosity, plasma viscosity and fibrino- gen level in group B were lower than those in group A, the differences were statistically significant （P〈0.05）. The incidence of adverse reactions in group B was significantly lower than that in group A （P〈0.05）. Conclusion The combination of clopido- grel and aspirin in patients with transient ischemic attack can effectively improve the clinical effect of the patients.