高危型人乳头瘤病毒负荷量与宫颈病变的关系研究

Study on the relationship between high risk human papillomavirus load and cervical lesions

目的探讨高危型人乳头瘤病毒负荷量与宫颈病变的关系。方法选择2013年10月至2016年10月在我院妇科进行高危型人乳头瘤病毒负荷量检测的2 538例患者,按照患者病毒负荷量将其分为三组:1~100 pg/mL设为A组;101~500 pg/mL设为B组;>500 pg/mL设为C组。统计和记录796例阳性感染病变患者的宫颈病变情况。结果 796例阳性感染病变患者中,经病理检查确诊为412例。其中,宫颈炎253例,宫颈上皮内瘤变150例,宫颈癌9例。在宫颈病变患者中,相比宫颈炎和上皮内瘤变,宫颈癌的HPV负荷量最高(P<0.05);C组的宫颈癌发病率明显高于A、B组,差异具有统计学意义(P<0.05)。结论高危型人乳头瘤病毒负荷量和宫颈病变有着密切的关系,且随着患者年龄的增加,出现宫颈瘤样变和癌变的风险越大。

Objective To study the relationship between high risk human papillomavirus load and cervical lesions. Methods From October 2013 to October 2016 in our hospital, 2 538 patients with high risk HPV load were examined, which were divided into three groups according to their viral load： 1-100 pg/mL was set as the group A; 101-500 pg/mL was set as the group B; 〉 500 pg/mL was set as the group C. The cervical lesions in 796 patients with positive infection were recorded. Results Of the 796 patients with positive infection, 412 cases were confirmed by pathological examination. Among them, 253 cases were cervicitis, 150 cases were cervical intraepithelial neoplasia, 9 cases were cervical cancer. In cervical disease patients, compared with cervicitis and intraepithelial neoplasia, the HPV load of cervical cancer was the highest （P〈0.05）. The incidence rate of cervical cancer in the group C was higher than that in the group A and group B （P〈 0.05）. Conclusion There is a close relationship between the risk of HPV and the cervical lesions, and the risk of cervical neoplasia and eanceration is increasing with the increase of the patients＇ age.