摘要
目的探讨重症肌无力（MG）患者血浆中血小板源性生长因子（PDGF）的表达水平及其临床意义。方法收集2015年8月至2016年12月期间于哈尔滨医科大学附属第二医院住院的44例MG患者和33名同期在本院进行体检的健康志愿者的血浆标本，采用MILLIPLEX MAP试剂盒检测血浆中PDGF表达量，进一步分析PDGF表达水平与MG患者临床特征、MG患者的严重程度（QMG评分）的相关性。结果PDGF在MG患者血浆中的表达水平（5．8±1．3）显著低于健康对照组（10．1±2．2），差异有统计学意义（t’=-9．767，P=0．000〈0．05）。PDGF的表达水平与QMG呈正相关（r=0．777，P〈0．01），PDGF的表达水平在不同MG亚组中差异无统计学意义。结论PDGF在MG患者血浆中的表达水平下降，可能与肌无力的严重程度呈正相关，PDGF的表达水平与发病年龄、性别、胸腺病理无明显关联。
Objective To evaluate the expression and clinical significance of plasma platelet derived growth factor （PDGF） in the patients with myasthenia gravis （MG）. Methods Plasma samples from 44 MG patients and 34 healthy people were collected from August 2015 to December 2016 from the Second Affiliated Hospital of Harbin Medical University. The expression of PDGF was detected by MILLIPLEX MAP Reagent kit. Furthermore, we analyzed the associations between PDCF expression level and quantitative myasthenia gravis score （QMG）. Result The expression of PDGF in plasma was significant lower in MG patients （5.8 ± 1.3 ） compared with control group （ 10.1± 2.2） , and the difference was statistically significant （ t＇ = - 9. 767, P 〈 0. 001 ）. Meanwhile it was positively related to QMG （ r = 0. 777, P 〈 0. 01 ）. However, no significant difference in expression of PDGF in MG subgroups was observed. Conclusion The expression of PDGF decreases in MG patients, has positive correlation with MG severity, and is not related to age, sex and the pathology of thymus samples.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2017年第37期2890-2893,共4页
National Medical Journal of China
基金
国家自然科学基金（81371324,81571166,81701190）
黑龙江省卫生计生委科研课题（2016-052,2016-072）
哈尔滨医科大学创新基金（2017LCZX57,2017LCZX65）
