腹腔微环境与结直肠癌腹膜转移关系的研究进展

Advances in the relationship between peritoneal microenvironment and peritoneal metastasis in colorectal cancer

腹膜转移是结直肠癌(colorectal cancer,CRC)常见的转移方式之一,通常预示着患者不良的预后。腹膜衬贴于腹盆壁内面和腹盆腔各脏器的表面,具有丰富的血液供应和大量常驻和迁移到此处的特定类型的细胞。腹腔中的多种细胞成分,细胞外基质以及局部特殊的理化性质共同构成了一个复杂和相对稳定的腹腔微环境;多种细胞在此环境中可以被结直肠癌细胞所诱导,参与并为肿瘤的生长、侵袭和腹膜转移提供适宜的"土壤"。本文就这些腹腔中参与构成腹腔微环境的主要细胞成分进行综述。

Peritoneal metastasis is very common in colorectal cancer and often indicates bad prognosis. The peritoneum, which contains an abundant supply of blood and specific types of resident and migrating cells, lines the surface of the abdominal wall and covers the abdominal organs. The combination of cells, extracellular matrix, and local unique physicochemical composition of the abdominal cavity provide a complex and relatively stable peritoneal microenvironment. The cells in this environment can be induced by cancer cells to be involved in tumor growth, invasion, and peritoneal metastasis. This review summarizes the major cellular components involved in the peritoneal microenvironment.