卵巢癌血清新型肿瘤标志物研究与应用现况

Research and Application of New Serum Tumor Markers in Ovarian Cancer

卵巢癌是妇科常见恶性肿瘤之一,死亡率高居榜首,早期诊断率仅30%,提高早期诊断水平对改善预后具有重要意义。近年来,筛查技术发生了巨大革新,各种新型肿瘤标志物被相继发现,联合检测多种肿瘤标志物、液体活检、液态芯片技术等在肿瘤早期筛查中日益重要,对于提高卵巢癌早期诊断水平、改善治疗效果、降低患者病死率等具有重要意义。本文对卵巢癌诊断相关肿瘤标志物新进展进行综述。

Ovarian cancer,with the highest mortality,is one of the common malignant tumors in gynecology.As the early diagnosis rate is only about 30%,enhancing the level of early diagnosis is of great significance to improve the prognosis.Detecting tumor markers has become a vital means of early diagnosis.In recent years,great innovations have taken place in screening technology.Various new types of tumor markers have been found constantly.Combined detection of multiple tumor markers,liquid biopsy and liquid chip are becoming more and more important in the early tumor detection,and have a considerable effect on the enhancement of early diagnosis of ovarian cancer,the improvement of treatment effect and decreasing case fatality rate.Herein,we review the new progress of tumor markers related to diagnosis of epithelial ovarian cancer.