高胆固醇血症对首发中年抑郁症患者认知功能的影响

Effect of hypercholesterolemia on cognitive function in patients with first onset depression

目的探讨高胆固醇血症对首发中年抑郁症患者认知功能的影响,从而为临床治疗及预防提供可靠的理论依据。方法 2017年2-7月该院就诊的首发中年抑郁症患者,均为右利手。筛选出伴有高胆固醇血症的抑郁症患者作为研究组(n=58),不伴有高胆固醇血症的抑郁症患者作为对照组(n=60),利用认知功能测评工具(韦氏成人智能量表、韦氏记忆量表、WCST)分别对两组进行认知功能的测评,并对两组进行认知功能的对照性评估。结果研究组的数字广度、图画填空、再认和持续性错误数与对照组比较差异有统计学意义(P<0.05)。结论高胆固醇血症可加重抑郁症患者认知功能的损害。

Objective To investigate the effect of hypercholesterolemia on cognitive function in patients with first-episode middle-aged depression,so as to provide a reliable theoretical basis for clinical treatment and prevention.Methods Middle-aged depressive disorder patients who received treatment of the first onset of depression in the hospital were all right-handed.Depressive disorder patients with hypercholesterolemia were selected as study group（n=58）,and depression patients without hypercholesterolemia served as control group（n=60）.The cogntion assessment tools（Wechsler Adult Intelligence Scale,Wechsler Memory Scale and WCST）were used to evaluate the cognitive function of two groups,and the cognitive function of two groups was compared.Results Digital span,fill in the blanks,recognition,and persistent error number of study group were significantly different as compared with those of control group（P〈0.05）.Conclusion Hypercholesterolemia aggravates the cognitive impairment in patients with depression.