中老年臂踝脉搏波传导速度与动脉硬化危险因素的关系

Correlation between brachial-ankle pulse wave velocity and risk factors for arteriosclerosis in middle-aged and elderly patients

目的探讨中老年患者臂踝脉搏波传导速度(baPWV)与动脉硬化危险因素的关系。方法通过对2012-2016年沈阳市第十人民医院心内科住院治疗行baPWV测定的360例患者数据进行统计,其中符合入选标准、资料完整的186例纳入统计分析。按照baPWV测定结果分为两组:非动脉硬化组(baPWV<1 400cm/s)61例和动脉硬化组(baPWV≥1 400cm/s)125例。通过多因素logistic回归分析发现对baPWV有意义的危险因素。结果与非动脉硬化组比较,动脉硬化组的年龄、静息心率、高血压严重程度、baPWV明显高于非动脉硬化组(P<0.05)。baPWV的多因素logistic回归分析:除年龄、吸烟史外,高血压分级、静息心率是baPWV的独立危险因素(OR=3.220,95%CI=1.912~5.422,P=0.000;OR=2.226,95%CI=0.897~5.524,P=0.085;OR=2.175,95%CI=1.583~2.990,P=0.000;OR=3.523,95%CI=1.654~7.506,P=0.001);血清总胆红素是保护因素(OR=0.378,95%CI=0.152~0.937,P=0.036)。结论增龄、吸烟、高血压水平、静息心率是动脉僵硬度增加的独立危险因素,而总胆红素是保护因素。

Objective To explore the relatioanship between brachial-ankle pulse wave velocity（baPWV）and risk factors for arteriosclerosis in middle-aged and elderly patients.Methods The patients who admitted in the hospital from 2012 to 2016 were analyzed in baPWV.The inclusion criteria of 186 cases were recruited into this survey.According to the baPWV levels,the patients were divided into two groups：arteriosclerosis group（baPWV≥1 400cm/s）and normal group（baPWV〈1 400cm/s）.The correlation between baPWV and risk factors for arteriosclerosis was analyzed by multivariate logistic regression analysis.Results The age,resting heart rate（RHR）,hypertension levels and baPWV of arteriosclerosis group were significantly higher than those of normal group（P〈0.05）.The multivariate logistic regression analysis showed that hypertension levels and RHR were the independent risk factors of baPWV increase for middle-aged and elderly patients except for age and smoking history（OR=3.220,95%CI=1.912-5.422,P=0.000;OR=2.226,95%CI=0.897-5.524,P=0.085;OR=2.175,95%CI=1.583-2.990,P=0.000;OR=3.523,95%CI=1.654-7.506,P=0.001）.Serum total bilirubin was a protective factor（OR=0.378,95%CI=0.152-0.937,P=0.036）.Conclusion Age and smoking,hypertension levels,RHR were the independent risk factors of baPWV increase for middle-aged and elderly patients,serum total bilirubin was a protective factor.