艾司西酞普兰与帕罗西汀治疗强迫症的疗效比较

Comparison of the efficacy between escitalopram and paroxetine in the treatment of obsessive compulsive disorder

目的:研究艾司西酞普兰与帕罗西汀治疗强迫症的疗效。方法:收集2015年2月-2017年2月收治的强迫症患者54例,随机分为对照组27例,采用帕罗西汀治疗,观察组27例,采用艾司西酞普兰治疗,两组均治疗8周。用强迫症评定量表和汉密尔顿抑郁量表对患者症状进行评分,比较两组治疗有效率和不良反应发生率。结果:观察组有效率为77.78%(21/27),对照组有效率为74.07%(20/27),组间差异无统计学意义(P>0.05)。治疗8周后,两组症状评分均较治疗前下降(P<0.05),尤其在治疗第1周时,观察组评分下降较对照组更为明显(P<0.05)。观察组不良反应发生率为11.11%(3/27),对照组不良反应发生率33.33%(9/27),组间差异有统计学意义(P<0.05)。结论:强迫症患者应用艾司西酞普兰和帕罗西汀治疗效果均较好,但艾司西酞普兰用药起效更快,安全性更高,患者产生的不良反应更少,值得推广应用。

Objective： To study the efficacy of escitalopram and paroxetine in the treatment of obsessive compulsive disorder. Methods： In our hospital 54 patients with obsessive compulsive disorder were collected from February 2015 to February 2017 and randomly divided into a control group with 27 cases treated with paroxetine, an observation group with 27 cases treated with escitalopram, and both groups were treated for 8 weeks. The symptom scores were evaluated by the obsessive compulsive rating scale and the Hamilton depression scale, and the effective rates of the two groups and the incidence of adverse reactions were compared. Results： The effective rate of the observation group was 77.78%（21/27）, that of the control group was 74.07%, and there was no significant difference between the two groups（P〉0.05）. After 8 weeks, the symptom scores of the two groups were lower than those before treatment（P〈0.05）, especially at first week after treatment, the score of the observation group was lower than that of the control group（P〈0.05）. The incidences of adverse reactions were 11.11%（3/27） in the observation group and 33.33%（9/27） in the control group, and the difference between the two groups was statistically significant（P〈0.05）. Conclusion： The effect of escitalopram and paroxetine was better in the treatment of obsessive compulsive disorder patients, but escitalopram works faster, its safety is higher, and the patients have fewer adverse reactions, which is worthy of popularization and application.