蓝光联合茵栀黄治疗新生儿病理性黄疸效果

Therapeutic effect of blue light combined with Yinzhihuang in the treatment of neonatal pathological jaundice

目的:观察蓝光联合茵栀黄治疗新生儿病理性黄疸的效果。方法:收集2014年10月-2016年8月儿科收治的新生儿病理性黄疸患儿100例,随机分为治疗组和对照组各50例。两组均实施常规对症治疗,同时对照组给予蓝光治疗,治疗组给予蓝光和茵栀黄治疗。记录两组疗效、不良反应、黄疸消退时间以及血清胆红素水平。结果:治疗组总有效率为92.0%(46/50),高于对照组的72.0%(36/50,P<0.05)。治疗后两组血清胆红素含量均较治疗前下降,治疗组较对照组更为显著(P<0.05)。治疗组患儿黄疸平均消退时间为(4.01±0.83)d,对照组为(5.91±1.01)d,组间差异有统计学意义(P<0.05)。治疗前后两组肝肾功能、血常规及尿常规检查均无显著变化,且均无严重不良反应。结论:蓝光联合茵栀黄治疗新生儿病理性黄疸疗效显著,且不良反应少,安全可靠,值得临床应用和推广。

Objective： To observe the therapeutic effect of blue light combined with Yinzhihuang in the treatment of neonatal pathological jaundice. Methods： From October 2014 to August 2016, 100 cases of pathological neonatal jaundice in the Department of Pediatrics were collected, and randomly divided into a treatment group and a control group with 50 cases in each group. The two groups were treated with conventional symptomatic treatment, while the control group was given blue light treatment, and the treatment group was given blue light and Yinzhihuang treatment. The therapeutic effect, adverse reaction, jaundice extinction time and serum bilirubin level of the two groups were recorded. Results： The total effective rate of the treatment group was 92%（46/50）, which was higher than that of the control group 72%（36/50, P〈0.05）. After treatment, serum bilirubin levels of the two groups were lower than those before treatment, and the treatment group was more significant than the control group（P〈0.05）. The average regression time of jaundice in the treatment group was （4.01＋0.83） d, that in the control group was （5.91＋1.01） d, and the difference between the two groups was statistically significant（P〈0.05）. There were no significant changes in liver and kidney function, routine blood test and urine routine examination before and after treatment, and there were no serious adverse reactions in the two groups. Conclusion： The therapeutic effect of Yinzhihuang combined with blue light in the treatment of neonatal pathological jaundice is remarkable, and adverse reactions are less, it is safe and reliable. It is worthy of clinical application and popularization.