海蟾蜍毒素与盐敏感性高血压研究进展

Research Progress of Marinobufagin and Salt Sensitivity Hypertension

盐敏感性高血压是一种特殊类型的高血压,因其特殊的发病机制和临床特征,近年来受到越来越多的关注;海蟾蜍毒素是一种内源性洋地黄类物质,是人类和动物体内广泛分布的Na+/K+-ATP酶的单一性配体;海蟾蜍毒素通过阻断钠钾ATP酶及多种信号途径介导水钠潴留、血压升高、心肌和血管纤维化等多种病理机制,在盐敏感性高血压的发生发展中发挥重要作用,本综述就海蟾蜍毒素与盐敏感性高血压的相关关系最新研究进展情况作综合介绍。

Salt-sensitive hype rtension is a special type of hypertension.Because of its special pathogenesis and clinical features,it has attracted more and more attention in recent years.Marinobufagenin is a kind of endogenous digitalis-like substance,which is the unitary ligand of Na＋/K＋-ATPase widely distributed in human and animal.Marinobufagenin mediated water sodium retention,increased blood pressure,and interfered myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na＋/K＋ATPase and various signaling pathways,which played an important role in the occurrence and development of salt-sensitive hypertension.This article reviewed the latest research progress of the relation between marinobufagenin and salt-sensitive hypertension.