针灸结合中药治疗退变性下颈椎不稳临床疗效及对血管活性因子的影响

Clinical Curative Observation and Related Vascular Active Factors Impact of Acupuncture Combined Chinese Medicine Treatment on Degenerative Cervical Instability

目的:探讨针灸结合中药治疗退变性下颈椎不稳患者临床疗效及对血管活性因子的影响,为临床研究提供参考依据。方法:选择2013年1月—2015年12月120例退变性下颈椎不稳患者作为研究对象,采用随机数字表法分为观察组与对照组各60例,分别给予针灸结合中药治疗与单独针灸治疗,所有患者均治疗30 d,比较两组疗效,并抽取空腹血检测治疗前后血管活性因子一氧化氮(NO)及内皮素(ET)水平变化。结果:观察组总有效率95.0%明显高于对照组83.3%,差异有统计学意义(P<0.05)。治疗后两组临床症状构成比均明显降低,差异有统计学意义(P<0.05);观察组降低更明显(P<0.05)。观察组治疗后ET为(64.52±12.47)ng/L,NO为(38.54±9.99)μmmol/L,与治疗前比较ET(88.89±12.92)ng/L,NO(62.64±10.11)μmmol/L,差异有统计学意义(P<0.05)。对照组治疗后ET为(73.44±12.25)ng/L,NO为(47.84±10.12)μmmol/L,明显低于治疗前(88.90±14.21)ng/L,(62.41±9.72)μmmol/L,差异有统计学意义(P<0.05)。且治疗后观察组明显低于对照组,差异有统计学意义(P<0.05)。结论:针灸联合中药治疗退变性下颈椎不稳患者有更好的临床疗效,在有效改善患者症状的同可时以更明显降低血管活性因子。

Objective：To study the clinical curative observation and related vascular active factors impact of acupuncture combined Chinese medicine treatment on degenerative cervical instability. Methods：A total of 120 patients with de- generative cervical instability were included from January 2013 to December 2015. All patients were divided into observation group and control group. Patients in observation group were given acupuncture combined Chinese medicine treatment and those in control group were given acupuncture treatment. After followed up for 30 days, curative effect and vascular active factors were compared. Endothelin （ET） and nitric oxide （NO） changes before and after treatment were compared. Results ：The total effective rate in observation group was 95.0% , which was higher than 83.3% in control group. The difference was statistically significant （ P 〈 0. 05）. The clinical symptoms after treatment were significantly lower than those before treatment. The difference were statistically significant （ P 〈 0. 05 ） , which in observation group reduced more significantly （ P 〈 0. 05 ）. The ET and NO in observation group after treatment were （64.52 ± 12.47 ） ng/L and （ 38.54 ±9.99） μmmol/L, respectively, which were lower than （88.89 ± 12.92） ng/L and （62.64 ± 10.11 ） μmmol/L before treatment. The difference were statistically significant （P 〈 0. 05 ）. The ET and NO in control group after treatment were （73.44 ± 12.25 ） ng/L and （47.84 ± 10.12） μmmol/L, respectively, which were lower than （ 88.90 ± 14.21 ） ng/L and （62.41 ±9.72） μmmol/L before treatment. The difference were statistically significant （P 〈0. 05 ）. The ET and NO in observation group after treatment were lower than that in control group. The difference were statistically significant （P 〈 0. 05）. Conclusion： Acupuncture combined Chinese medicine treating degenerative cervical instability has a better