摘要
人类多聚蛋白1(MMRN1)是存在于血小板和血管内皮中,且主要储存在α颗粒中的一种可溶性蛋白质。它由链间二硫键连接的亚基组成,可形成一系列同源多聚体。MMRN1是Ⅴ/Ⅴa的结合蛋白因子,可作为血小板因子Ⅴ的载体蛋白,与细胞外基质形成特定配体,具有黏附蛋白等生物学功能。在国外,以MMRN1基因作为靶蛋白研究其与人类疾病的关系,以及以MMRN1作为目标基因进行动物模型实验逐渐成为研究热点,故对MMRN1基因的探索可作为研究多种疾病的切入点之一。
Multimerin 1（ MMRN1） is a massive,soluble protein found in platelets and in the endothelium of blood vessels. It is a soluble protein that is mainly stored in alpha-particles and comprised of subunits linked by interchain disulfide,and can form a series of homologous multimers. MMRN1 is a factorⅤ/Ⅴa-binding protein and may function as a carrier protein for platelet factor Ⅴ,which may also have biological functions as an extracellular matrix or adhesive protein. At abroad,study on MMRN1 gene as a target protein and its relationship with human disease,and MMRN1 as the target gene for animal model experiment has gradually become a research hotspot,so the exploration of MMRN1 gene can be used as one of the entry points for study of multiple diseases.
出处
《医学综述》
2017年第19期3750-3753,共4页
Medical Recapitulate
