活性维生素D在系统性红斑狼疮中的作用研究

Study on the Role of Vitamin D in Systemic Lupus Erythematosus

活性维生素D是一种具有多种生物学效应的激素前体,其与靶细胞上维生素D受体结合发挥作用。它是体内钙磷代谢的重要参与者,与细胞周期,细胞增殖、分化、凋亡、信号转导和免疫调节关系密切,其在感染、肿瘤甚至风湿病治疗中的作用也逐渐被认识和研究。系统性红斑狼疮患者体内活性维生素D水平普遍下降,低水平的维生素D与疾病的发生、疾病活动度及并发症发生均存在联系。早期筛查及对症补充活性维生素D可能有利于SLE患者疾病的预后。

Active vitamin D is a hormone precursor with a variety of biological effects,and it plays a role by combining with vitamin D receptor on the target cells. It is an important participant of calcium phosphorus metabolism in the body,which takes part in cell proliferation,differentiation,apoptosis and cell cycle,signal transduction,and immune regulation,and its role in the treatment of infection,tumor and even rheumatic disease are also recognized and studied gradually. Active vitamin D levels in patients with systemic lupus erythematosus are declined generally,and low levels of vitamin D are associated with the occurrence,activity and complications of the disease. Early screening and supplementation of active vitamin D may benefit for the prognosis of patients with SLE.