慢阻肺急性加重期病人肠内营养支持的临床观察

Clinical observation of enteral nutrition support in patients with acute exacerbation of chronic obstructive pulmonary disease

目的:探讨肠内营养(EN)对慢阻肺急性加重期病人临床效果的影响。方法:选取2015年1月到2016年12月在我科治疗的慢阻肺急性加重期病人96例,随机分成观察组48例和对照组48例(常规饮食),二组病人均给予抗感染及相关对症治疗,观察组给予肠内营养支持治疗,2周后比较二组的血清蛋白和肺功能变化,观察两组病人抗菌药物使用天数、住院天数、3月内再入院率。结果:观察组在经治疗后血清白蛋白(ALB)、前白蛋白(PA)、FEV1、FEV1/FVC较对照组明显提高,抗菌药物使用天数、住院天数、3月内再住院率均明显降低,P<0.05,差异具有统计学意义。结论:肠内营养可以改善慢阻肺急性加重期病人的营养状况和肺功能,缩短住院时间及抗菌素使用天数,减少再住院率,促进病人康复,值得临床广泛使用。

Objective： To investigate the clinical effect of enteral nutrition（EN） on patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods： 96 cases of acute exacerbation of COPD patients admitted to our hospital from January 2015 to December 2016 were randomly divided into observation group（48 cases） and control group（normal diet, 48 cases）. The patients in two groups were given anti-infection and other symptomatic treatments equally. The serum protein levels and pulmonary function in the two groups were compared after 2 weeks. Furthermore, antibiotic use durations, hospitalization days and the re-admission rates within 3 months were observed and compared between two groups. Results： The serum albumin and pre-albumin levels, FEV1 and FEV1/FVC in the observation group were significantly elevated in comparison with those in the control group. And the antibiotic use durations, hospitalization days and the re-admission rates within 3 months remarkably decreased in the observation group（ P〈0.05）. Conclusion： Enteral nutrition could improve the nutritional status and pulmonary function in patients with acute exacerbation of COPD, shortening the length of hospital stay and the durations of antibiotic use and reducing the rates of re-admission. Enteral nutrition may be worth applying widely in clinical COPD patients in future.