两种粒径连翘粉的重复给药毒性作用比较研究

Comparative Study on the Toxic Effects of Repeated Administration of Two Kinds of Forsythia Powder

目的:研究连翘超微粉与普通粉连续灌胃给药4周对大鼠的毒性。方法:将140只大鼠随机分为7组:药物组大鼠分别灌胃连翘超微粉与普通粉4、8、16g/kg,对照组大鼠灌胃相同体积的纯净水,给药4周后,每组随机抽取10只大鼠,进行生化检测和病理解剖;剩余的动物在停药2周后进行可逆性实验检测。结果:连翘超微粉与普通粉对大鼠的血液生化学指标无明显的毒性,对大鼠的脏器形态学检查亦未发现有明显损伤性毒性变化。结论:连翘超微粉与普通粉长期服用毒性低,临床用药安全。

Objective：To study the toxicity of Forsythia superfine powder and common powder after 4 weeks＇ continuous intragastric administration. Methods： 140 rats were divided into 7 groups randomly： The rats in the drug group were treated with superfine powder and common powder by 4, 8,16g/kg, rats in the control group were given the same volume of purified water. 10 rats were selected randomly from each group after four weeks＇ administration, and biochemical test, pathological anatomy were carried on. The remaining rats were sacrificed for reversible experiment after 2 weeks of withdrawal drug. Results： Both Forsythia superfine powder and common powder had no significant toxicity on the blood biochemical indexes of the rats. No significant damage was observed on the organ of rats. Conclusion：Forsythia superfine powder and common powder were in low toxicity with long time use, they are safe in clinic practice.