柳珊瑚来源真菌Penicillium chrysoygenum中聚酮-萜类化合物citrehybridonol及其单晶结构

Meroterpenoid citrehybridonol from gorgonian-derived fungus Penicillium chrysogenum and its single-crystal structure

目的柳珊瑚来源真菌Penicillium chrysogenum中聚酮-萜类化合物citrehybridonol及其晶体结构和生物活性研究。方法利用核磁、质谱等现代波谱分析方法和X-ray单晶衍射技术,对citrehybridonol的化学结构进行研究;运用细胞毒活性和抗菌活性模型对其生物活性进行评价。结果 Citrehybridonol为分离获得其晶体,并对其单晶数据进行报道。生物活性测试结果表明,该化合物对测试的细菌菌株未显示抗菌活性,对肿瘤细胞株未见细胞毒活性。结论 Citrehybridonol的单晶数据以及活性数据对今后系统研究聚酮-萜类化合物具有参考价值。

Objective To study the meroterpenoid citrehybridonol isolated from the gorgonian-derived fungus Penicillium chrysogenum and its crystal structure and bioactivity. Methods The chemical structure of citrehybridonol was determined by extensive NMR and MS spectroscopic data, and its stereochemicl structure was established by X-ray diffraction of single-crystal. The bioactivities were evaluated using eytotoxie and antibacterial models. Results The single-crystal data of citrehybridonol was obtained and reported for the first time. Citrehybridonol was found to be inactive against the tested bacteria and cancer cell lines. Conclusion The data of single-crystal and biological activities provided references for the systematic study of citrehybridonol and its analogues in the future.