摘要
A gold-catalyzed intermolecular reaction of ynamides with 3-indolyl azides via the presumable a-imino gold carbenes has been developed, providing an alternative and efficient way for the synthesis of valuable 3-amino-b-carbolines in generally good to excellent yields. Importantly, this new protocol involves an unexpected 1,2-alkyl migration pathway.
A gold-catalyzed intermolecular reaction of ynamides with 3-indolyl azides via the presumable α-imino gold carbenes has been developed, providing an alternative and efficient way for the synthesis of valuable 3-amino-β-carbolines in generally good to excellent yields. Importantly, this new protocol involves an unexpected 1,2-alkyl migration pathway.
基金
supported by the National Natural Science Foundation of China (21622204 and 21572186)
the Natural Science Foundation of Fujian Province for Distinguished Young Scholars (2015J06003)
the President Research Funds from Xiamen University (20720150045)
NFFTBS (J1310024)
